Congenital Heart Defects and Measures of Fetal Growth in Newborns with Down Syndrome or 22q11.2 Deletion Syndrome

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Congenital Heart Defects and Measures of Fetal Growth in Newborns with Down Syndrome or 22q11.2 Deletion Syndrome. / Matthiesen, Niels B; Agergaard, Peter; Henriksen, Tine B; Bach, Cathrine C; Gaynor, J William; Hjortdal, Vibeke; Østergaard, John R.

I: The Journal of Pediatrics, Bind 175, 08.2016, s. 116-122.e4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Matthiesen, NB, Agergaard, P, Henriksen, TB, Bach, CC, Gaynor, JW, Hjortdal, V & Østergaard, JR 2016, 'Congenital Heart Defects and Measures of Fetal Growth in Newborns with Down Syndrome or 22q11.2 Deletion Syndrome', The Journal of Pediatrics, bind 175, s. 116-122.e4. https://doi.org/10.1016/j.jpeds.2016.04.067

APA

Matthiesen, N. B., Agergaard, P., Henriksen, T. B., Bach, C. C., Gaynor, J. W., Hjortdal, V., & Østergaard, J. R. (2016). Congenital Heart Defects and Measures of Fetal Growth in Newborns with Down Syndrome or 22q11.2 Deletion Syndrome. The Journal of Pediatrics, 175, 116-122.e4. https://doi.org/10.1016/j.jpeds.2016.04.067

Vancouver

Matthiesen NB, Agergaard P, Henriksen TB, Bach CC, Gaynor JW, Hjortdal V o.a. Congenital Heart Defects and Measures of Fetal Growth in Newborns with Down Syndrome or 22q11.2 Deletion Syndrome. The Journal of Pediatrics. 2016 aug.;175:116-122.e4. https://doi.org/10.1016/j.jpeds.2016.04.067

Author

Matthiesen, Niels B ; Agergaard, Peter ; Henriksen, Tine B ; Bach, Cathrine C ; Gaynor, J William ; Hjortdal, Vibeke ; Østergaard, John R. / Congenital Heart Defects and Measures of Fetal Growth in Newborns with Down Syndrome or 22q11.2 Deletion Syndrome. I: The Journal of Pediatrics. 2016 ; Bind 175. s. 116-122.e4.

Bibtex

@article{c305ce91b43a4a2b9ae0ed2619dd7a03,

title = "Congenital Heart Defects and Measures of Fetal Growth in Newborns with Down Syndrome or 22q11.2 Deletion Syndrome",

abstract = "OBJECTIVES: To estimate the association between congenital heart defects (CHD) and indices of fetal growth in Down and 22q11.2 deletion syndromes.STUDY DESIGN: We established 2 Danish nationwide cohorts of newborn singletons with either Down syndrome (n = 670) or 22q11.2 deletion syndrome (n = 155), born 1997-2011. In both cohorts, we analyzed the association between CHD, CHD severity, and indices of fetal growth by multivariable linear regression adjusted for potential confounders. We report mean differences in gestational age specific z-scores compared with newborns without CHD.RESULTS: Down syndrome and 22q11.2 deletion syndrome were both associated with lower mean birth weight and head circumference z-scores. We found no association between CHD or CHD severity and indices of fetal growth. In Down syndrome, the association between any CHD and the mean difference in head circumference z-score was 0.03 (95% CI -0.12, 0.18), and the estimate regarding birth weight z-score was 0.09 (95% CI -0.08, 0.25). The corresponding estimates in 22q11.2 deletion syndrome were 0.00 (95% CI -0.33, 0.32) and -0.09 (95% CI -0.45, 0.26).CONCLUSIONS: We found no association between CHD and fetal growth measures in newborns with Down syndrome or 22q11.2 deletion syndrome. Thus, in certain subtypes of CHD, the contribution of genetic factors to prenatal growth impairment may be more important than circulatory disturbances.",

keywords = "Birth Weight, Cephalometry, DiGeorge Syndrome/embryology, Down Syndrome/embryology, Female, Fetal Development/genetics, Head/anatomy & histology, Heart Defects, Congenital/embryology, Humans, Infant, Newborn, Linear Models, Male, Registries, Severity of Illness Index",

author = "Matthiesen, {Niels B} and Peter Agergaard and Henriksen, {Tine B} and Bach, {Cathrine C} and Gaynor, {J William} and Vibeke Hjortdal and {\O}stergaard, {John R}",

year = "2016",

month = aug,

doi = "10.1016/j.jpeds.2016.04.067",

language = "English",

volume = "175",

pages = "116--122.e4",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

}

RIS

TY - JOUR

T1 - Congenital Heart Defects and Measures of Fetal Growth in Newborns with Down Syndrome or 22q11.2 Deletion Syndrome

AU - Matthiesen, Niels B

AU - Agergaard, Peter

AU - Henriksen, Tine B

AU - Bach, Cathrine C

AU - Gaynor, J William

AU - Hjortdal, Vibeke

AU - Østergaard, John R

PY - 2016/8

Y1 - 2016/8

N2 - OBJECTIVES: To estimate the association between congenital heart defects (CHD) and indices of fetal growth in Down and 22q11.2 deletion syndromes.STUDY DESIGN: We established 2 Danish nationwide cohorts of newborn singletons with either Down syndrome (n = 670) or 22q11.2 deletion syndrome (n = 155), born 1997-2011. In both cohorts, we analyzed the association between CHD, CHD severity, and indices of fetal growth by multivariable linear regression adjusted for potential confounders. We report mean differences in gestational age specific z-scores compared with newborns without CHD.RESULTS: Down syndrome and 22q11.2 deletion syndrome were both associated with lower mean birth weight and head circumference z-scores. We found no association between CHD or CHD severity and indices of fetal growth. In Down syndrome, the association between any CHD and the mean difference in head circumference z-score was 0.03 (95% CI -0.12, 0.18), and the estimate regarding birth weight z-score was 0.09 (95% CI -0.08, 0.25). The corresponding estimates in 22q11.2 deletion syndrome were 0.00 (95% CI -0.33, 0.32) and -0.09 (95% CI -0.45, 0.26).CONCLUSIONS: We found no association between CHD and fetal growth measures in newborns with Down syndrome or 22q11.2 deletion syndrome. Thus, in certain subtypes of CHD, the contribution of genetic factors to prenatal growth impairment may be more important than circulatory disturbances.

AB - OBJECTIVES: To estimate the association between congenital heart defects (CHD) and indices of fetal growth in Down and 22q11.2 deletion syndromes.STUDY DESIGN: We established 2 Danish nationwide cohorts of newborn singletons with either Down syndrome (n = 670) or 22q11.2 deletion syndrome (n = 155), born 1997-2011. In both cohorts, we analyzed the association between CHD, CHD severity, and indices of fetal growth by multivariable linear regression adjusted for potential confounders. We report mean differences in gestational age specific z-scores compared with newborns without CHD.RESULTS: Down syndrome and 22q11.2 deletion syndrome were both associated with lower mean birth weight and head circumference z-scores. We found no association between CHD or CHD severity and indices of fetal growth. In Down syndrome, the association between any CHD and the mean difference in head circumference z-score was 0.03 (95% CI -0.12, 0.18), and the estimate regarding birth weight z-score was 0.09 (95% CI -0.08, 0.25). The corresponding estimates in 22q11.2 deletion syndrome were 0.00 (95% CI -0.33, 0.32) and -0.09 (95% CI -0.45, 0.26).CONCLUSIONS: We found no association between CHD and fetal growth measures in newborns with Down syndrome or 22q11.2 deletion syndrome. Thus, in certain subtypes of CHD, the contribution of genetic factors to prenatal growth impairment may be more important than circulatory disturbances.

KW - Birth Weight

KW - Cephalometry

KW - DiGeorge Syndrome/embryology

KW - Down Syndrome/embryology

KW - Female

KW - Fetal Development/genetics

KW - Head/anatomy & histology

KW - Heart Defects, Congenital/embryology

KW - Humans

KW - Infant, Newborn

KW - Linear Models

KW - Male

KW - Registries

KW - Severity of Illness Index

U2 - 10.1016/j.jpeds.2016.04.067

DO - 10.1016/j.jpeds.2016.04.067

M3 - Journal article

C2 - 27245297

VL - 175

SP - 116-122.e4

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -

ID: 246355437

Institut for Klinisk Medicin