Health-related quality of life and cognitive function after out-of-hospital cardiac arrest; a comparison of prehospital return-of-spontaneous circulation and refractory arrest managed with extracorporeal cardiopulmonary resuscitation
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Extracorporeal cardiopulmonary resuscitation (ECPR) for selected refractory out-of-hospital cardiac arrest (OHCA) is increasingly used. Detailed knowledge of health-related quality of life (HRQoL) and long-term cognitive function is limited. HRQoL and cognitive function were assessed in ECPR-survivors and OHCA-survivors with prehospital return of spontaneous circulation after standard advanced cardiac life support (sACLS).
Methods
Fifteen ECPR-survivors and 22 age-matched sACLS-survivors agreed to participate in this follow-up study. Participants were examined with echocardiography, 6-minute walk test, and neuropsychological testing, and answered HRQoL (EQ-5D-5L and Short Form 36 (SF-36)), and mental health questionnaires.
Results
Most patients were male (73 % and 82 %) and median age at follow-up was similar between groups (55 years and 60 years). Low flow time was significantly longer for ECPR-survivors (86 min vs. 15 min) and lactate levels were significantly higher (14.1 mmol/l vs. 3.9 mmol/l). No between-group difference was found in physical function nor in cognitive function with scores corresponding to the 23rd worst percentile of the general population. SACLS-survivors had HRQoL on level with the Danish general population while ECPR-survivors scored lower in both EQ-5D-5L (index score 0.73 vs. 0.86, p = 0.03, visual analog scale: 70 vs. 84, p = 0.04) and in multiple SF-36 health domains (role physical, bodily pain, general health, and mental health).
Conclusions
Despite substantially longer low flow times with thrice as high lactate levels, ECPR-survivors were similar in cognitive and physical function compared to sACLS-survivors. Nonetheless, ECPR-survivors reported lower HRQoL overall and related to mental health, pain management, and the perception of limitations in physical role.
Originalsprog | Engelsk |
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Artikelnummer | 110151 |
Tidsskrift | Resuscitation |
Vol/bind | 197 |
Antal sider | 9 |
ISSN | 0300-9572 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
This project was supported by the common foundation of Rigshospitalet and Odense University Hospital (grant number 83-A3759), The Danish Heart Foundation (grant number 2020-9587) and by the Beckett Foundation (grant number 23-2-10125).
Funding Information:
JK has a research grant from Novo Nordisk Foundation (NNF22OC0079649) outside the submitted work. HS has a research grant from Novo Nordisk Foundation outside the submitted work. CH has a research grant from Novo Nordisk Foundation, Lundbeck Foundation and The Danish Heart Foundation outside the submitted work. JEM has a research grant from Novo Nordisk Foundation, Abiomed and The Danish Heart Foundation outside the submitted work. None of the other authors have anything to declare.
Publisher Copyright:
© 2024 The Author(s)
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