Laser Speckle Contrast Imaging-based diagnosis of severe mesenteric traction syndrome: Hemodynamics and prostacyclin - A prospective cohort study
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Laser Speckle Contrast Imaging-based diagnosis of severe mesenteric traction syndrome : Hemodynamics and prostacyclin - A prospective cohort study. / Olsen, August Adelsten; Burgdorf, Stefan; Bigler, Dennis Richard; Siemsen, Mette; Aasvang, Eske Kvanner; Goetze, Jens P.; Svendsen, Morten Bo Søndergaard; Svendsen, Lars Bo; Achiam, Michael Patrick.
I: Microvascular Research, Bind 147, 104505, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Laser Speckle Contrast Imaging-based diagnosis of severe mesenteric traction syndrome
T2 - Hemodynamics and prostacyclin - A prospective cohort study
AU - Olsen, August Adelsten
AU - Burgdorf, Stefan
AU - Bigler, Dennis Richard
AU - Siemsen, Mette
AU - Aasvang, Eske Kvanner
AU - Goetze, Jens P.
AU - Svendsen, Morten Bo Søndergaard
AU - Svendsen, Lars Bo
AU - Achiam, Michael Patrick
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Brief abstract: Today, the diagnosis and grading of mesenteric traction syndrome relies on a subjective assessment of facial flushing. However, this method has several limitations. In this study, Laser Speckle Contrast Imaging and a predefined cut-off value are assessed and validated for the objective identification of severe mesenteric traction syndrome. Background: Severe mesenteric traction syndrome (MTS) is associated with increased postoperative morbidity. The diagnosis is based on an assessment of the developed facial flushing. Today this is performed subjectively, as no objective method exists. One possible objective method is Laser Speckle Contrast Imaging (LSCI), which has been used to show significantly higher facial skin blood flow in patients developing severe MTS. Using these data, a cut-off value has been identified. This study aimed to validate our predefined LSCI cut-off value for identifying severe MTS. Methods: A prospective cohort study was performed on patients planned for open esophagectomy or pancreatic surgery from March 2021 to April 2022. All patients underwent continuous measurement of forehead skin blood flow using LSCI during the first hour of surgery. Using the predefined cut-off value, the severity of MTS was graded. In addition, blood samples for prostacyclin (PGI2) analysis and hemodynamics were collected at predefined time points to validate the cut-off value. Main results: Sixty patients were included in the study. Using our predefined LSCI cut-off value, 21 (35 %) patients were identified as developing severe MTS. These patients were found to have higher concentrations of 6-Keto-PGFaα (p = 0.002), lower SVR (p < 0.001), lower MAP (p = 0.004), and higher CO (p < 0.001) 15 min into surgery, as compared with patients not developing severe MTS. Conclusion: This study validated our LSCI cut-off value for the objective identification of severe MTS patients as this group developed increased concentrations of PGI2 and more pronounced hemodynamic alterations compared with patients not developing severe MTS.
AB - Brief abstract: Today, the diagnosis and grading of mesenteric traction syndrome relies on a subjective assessment of facial flushing. However, this method has several limitations. In this study, Laser Speckle Contrast Imaging and a predefined cut-off value are assessed and validated for the objective identification of severe mesenteric traction syndrome. Background: Severe mesenteric traction syndrome (MTS) is associated with increased postoperative morbidity. The diagnosis is based on an assessment of the developed facial flushing. Today this is performed subjectively, as no objective method exists. One possible objective method is Laser Speckle Contrast Imaging (LSCI), which has been used to show significantly higher facial skin blood flow in patients developing severe MTS. Using these data, a cut-off value has been identified. This study aimed to validate our predefined LSCI cut-off value for identifying severe MTS. Methods: A prospective cohort study was performed on patients planned for open esophagectomy or pancreatic surgery from March 2021 to April 2022. All patients underwent continuous measurement of forehead skin blood flow using LSCI during the first hour of surgery. Using the predefined cut-off value, the severity of MTS was graded. In addition, blood samples for prostacyclin (PGI2) analysis and hemodynamics were collected at predefined time points to validate the cut-off value. Main results: Sixty patients were included in the study. Using our predefined LSCI cut-off value, 21 (35 %) patients were identified as developing severe MTS. These patients were found to have higher concentrations of 6-Keto-PGFaα (p = 0.002), lower SVR (p < 0.001), lower MAP (p = 0.004), and higher CO (p < 0.001) 15 min into surgery, as compared with patients not developing severe MTS. Conclusion: This study validated our LSCI cut-off value for the objective identification of severe MTS patients as this group developed increased concentrations of PGI2 and more pronounced hemodynamic alterations compared with patients not developing severe MTS.
KW - Facial flushing
KW - Intraoperative hemodynamics
KW - Laser Speckle Contrast Imaging
KW - Mesenteric traction syndrome
KW - Prostacyclin
U2 - 10.1016/j.mvr.2023.104505
DO - 10.1016/j.mvr.2023.104505
M3 - Journal article
C2 - 36801270
AN - SCOPUS:85149885247
VL - 147
JO - Microvascular Research
JF - Microvascular Research
SN - 0026-2862
M1 - 104505
ER -
ID: 347107400