Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
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Background: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. Methods: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. Results: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. Conclusion: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 22 |
| Tidsskrift | International Journal of Bipolar Disorders |
| Vol/bind | 11 |
| Udgave nummer | 1 |
| Antal sider | 9 |
| ISSN | 2194-7511 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Open Access funding enabled and organized by Projekt DEAL. Ole A. Andreassen is supportet by the Research Council of Norway (#223273) and the South Eastern Norway Health Region (#2019–108). Michael Berk is supported by a NHMRC Senior Principal Research Fellowship (1156072). Pierre A. Geoffroy, Chantal Henry and Josselin Houenou received grants from the French Agence Nationale pour la Recherche (ANR-11-IDEX-0004 Labex BioPsy “Olfaction and Bipolar Disorder” collaborative project, ANR-10-COHO-10–01 psyCOH and ANR-DFG ANR-14-CE35–0035 FUNDO). Seong Jae Kim is supported by research funds from the Institute of Medical Science, Chosun University, Republic of Korea, 2022. Mok Yee Ming, Mythily Subramaniam, and Wen Lin Teh received funding from the National Medical Research Centre (NMRC) Centre Grant (Ref No: NMRC/CG/M002/ 2017_IMH). Raj Ramesar is supported by the South African Department of Science and Innovation and Medical Research Council. Eduard Vieta acknowledges the support by CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB07/09/0004), Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation. EV thanks the support of the Spanish Ministry of Science and Innovation (PI18/00805, PI21/00787) integrated into the Plan Nacional de I + D + I and co-financed by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER); the Instituto de Salud Carlos III; the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017 SGR 1365), the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357. Thanks the support of the European Union Horizon 2020 research and innovation program (EU.3.1.1. Understanding health, wellbeing and disease: Grant No 754907 and EU.3.1.3. Treating and managing disease: Grant No 945151). Biju Viswanath is supported by the Intermediate (Clinical and Public Health) Fellowship (IA/CPHI/20/1/505266) of the DBT/ Wellcome Trust India Alliance.
Publisher Copyright:
© 2023, The Author(s).
ID: 367702402